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Related
Bodybuilders often take HGH in exogenous form to increase HGH production, increasing muscle mass and fat loss. Exogenous GH has the potential to decrease GH synthesis in muscle [10], and this in turn can lead to an increase in muscle cell size [1], but there's no conclusive evidence for the use of exogenous HGH for this purpose in humans. In this experiment, we measured the time required to produce muscle in the vastus lateralis during rest with and without HGH supplementation. The effect on HGH synthesis is the primary focus here, but as a secondary goal, we wanted to determine whether supplementation with anabolic steroids would have the same effect. After baseline measurements, we measured the rate of muscle synthesis (RMS) after a 3-hour fast. We then tested whether RMS would continue to increase in response to the increased levels of AAs in the body. Methods Experimental Approach to the Problem We used a double blind, placebo controlled, randomized, and cross over design to evaluate the acute influence, in a laboratory, of oral supplementation with HGH (Cav. HGH, 2% w/w), with or without anabolic steroids (Cav. AAS, 7.5 µg/kg). Subjects who reported an increased appetite were excluded from the study (n = 9). Subjects were free to return for the next session if they completed all the study time requirements. All subjects were screened using standard medical assessments administered by the researchers and the staff at the Clinical Laboratory Improvement Amendments. Subjects were informed that their participation involved a research study, an observational study, and a possible potential risk of serious bodily injury. All subjects gave written informed consent before participation in the study. All procedures were in accordance with the guidelines of the Human Research Ethical Committee of Yale University School of Medicine in New Haven, CT and the principles established by the NIH Consent/Research Ethics Committee that govern research with humans [21]. Subjects A total of 10 non-athlete (mean age, 21.2±3.7 yr, 7 men, 9 women; body mass index; 28±9 kg/m2) men aged 18–28 with and without anabolic steroid use history or a history of previous injuries were recruited into the study. Subjects were assessed after the 1st and 2nd sessions of treatment. Informed consent was obtained from all participants and written informed consent after the 2nd session was obtained from the subject. All the subjects provided written informed consent prior to the beginning of the study. HGH Supplementation HGH was taken Similar articles: